Coaches leave regularly from either Florenc bus station near Prague city centre, or more regularly from Cerny Most metro station (the eastern end of the B/Yellow line). The journey takes between three and four hours, depending on the number of stops en route, and where you start from. For full details of times, check the IDOS website. If your Czech is up to it, you can make a reservation online at http://www.svt.cz/amsbus/ (you still have to pay for the ticket in person at an AMS Bus counter 3 days in advance). When you get to Spindleruv Mlyn, you're depositied at the bus station a short walk from the town centre. Walk in the direction the bus was travelling just round the next corner to get to the town proper.